Effects of subinhibitory concentrations of vancomycin and teicoplanin on adherence of staphylococci to tissue culture plates
Carsenti-Etesse, H.; Durant, J.; Entenza, J.; Mondain, V.; Pradier, C.; Bernard, E.; Dellamonica, P.
Antimicrobial Agents and Chemotherapy 37(4): 921-923
1993
ISSN/ISBN: 0066-4804 PMID: 8494393 Document Number: 413616
Bacterial adhesion is the first step in infection of medical devices. Staphylococcus aureus and Staphylococcus epidermidis are the pathogens recovered most often. The effects of subinhibitory concentrations of vancomycin and teicoplanin on the adherence of eight clinical strains of S. aureus and eight strains of S. epidermidis to tissue culture plates in vitro were tested. The mean relative inhibitions of adherence at one-fourth and one-eighth the MIC were statistically different for teicoplanin and vancomycin. Slime production seemed not to be involved in adherence.