Effect of subinhibitory concentrations of antibiotics on catalase activity of plague microbes

Ryzhkova, V.V.; Blagorodova, N.S.; Mikhalevich, R.V.; Pavlovich, N.V.

Antibiotiki i Khimioterapiia 37(11): 21-23

1992


ISSN/ISBN: 0235-2990
PMID: 1300927
Document Number: 392106
It was shown that the presence of subinhibitory concentrations of ampicillin, cefotaxime or gentamicin in the cultivation medium had a marked inhibitory effect on the catalase activity of plague microbe. The effect depended on the characteristic features of plague microbe strains and the incubation temperature. When the cells of a virulent strain of the plague microbe Y. pestis 1300 were cultivated at a temperature of 37 degrees C on a medium containing the subinhibitory concentrations of ampicillin or cefotaxime, the pathogen virulence for albino mice significantly decreased.

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