Effect of subinhibitory concentrations of antibiotics on catalase activity of plague microbes
Ryzhkova, V.V.; Blagorodova, N.S.; Mikhalevich, R.V.; Pavlovich, N.V.
Antibiotiki i Khimioterapiia 37(11): 21-23
1992
ISSN/ISBN: 0235-2990 PMID: 1300927 Document Number: 392106
It was shown that the presence of subinhibitory concentrations of ampicillin, cefotaxime or gentamicin in the cultivation medium had a marked inhibitory effect on the catalase activity of plague microbe. The effect depended on the characteristic features of plague microbe strains and the incubation temperature. When the cells of a virulent strain of the plague microbe Y. pestis 1300 were cultivated at a temperature of 37 degrees C on a medium containing the subinhibitory concentrations of ampicillin or cefotaxime, the pathogen virulence for albino mice significantly decreased.