The inhibitory actions of protease inhibitors on the production of polymorphonuclear leukocyte elastase and interleukin 8
Endo, S.; Inada, K.; Yamashita, H.; Takakuwa, T.; Nakae, H.; Yamada, Y.; Kasai, T.; Taki, K.; Yoshida, M.
Research Communications in Chemical Pathology and Pharmacology 82(1): 27-34
1993
ISSN/ISBN: 0034-5164 PMID: 8272572 Document Number: 413513
The inhibitory actions of Ulinastatin, which is a protease inhibitor, on the production of polymorphonuclear leukocyte elastase (PMN-elastase) and interleukin 8 (IL-8) in vascular endothelial cells were evaluated. Our findings suggest that IL-8 plays a role in the production of PMN-elastase. Ulinastatin inhibited the lipopolysaccharide (LPS)-stimulated activity of polymorphonuclear leukocytes (PMN) and the production of IL-8 in vascular endothelial cells. Ulinastatin also inhibited the LPS-stimulated production of PMN-elastase in PMN.