Midazolam pharmacokinetics and electroencephalographic changes in eight Chinese men
Lu, J.F.; Wu, M.F.; Chen, G.; Xiang, B.R.; An, D.K.
Zhongguo Yao Li Xue Bao 14(6): 485-488
1993
ISSN/ISBN: 0253-9756 PMID: 8010043 Document Number: 413134
Eight Chinese healthy male volunteers aged 27+-s 4 a were injected iv midazolam (Mid) 15 mg. Blood samples were collected at 0, 2, 5, 7, 10, 20, 30, 45, 60, 90, 120, 180, and 240 min. A HPLC method was established for determining the Mid concentrations in serum. The concentration-time data was fitted with biexponential curve. Pharmacokinetic parameters were: T1/2-alpha = 6.8 +- 2.5 min, T1/2-beta = 118 +- 27 min, V-c = 25 +- 7 L, Cl = 393 +- 79 ml cntdot min-1, V-dss = 59 +- 13 L, AUC-0- infin - 39.6 +- 8.6 g cntdot min cntdot L-1. The electroencephalogram (EEG) showed a decrease in alpha activity and an increase in beta activity. The EEG pattern reverted toward baseline after 2-3 h. Pharmacokinetic and EEG findings suggest that Mid is a preferable anesthesia inducing agent.