Pharmacokinetics of norethindrone enanthate 200 mg after intramuscular injection in 25 Chinese women
Sang, G.W.; Liu, X.H.; Shao, Q.X.; Ge, J.L.; Mao, S.M.; Lu, F.Y.
Zhongguo Yao Li Xue Bao 12(2): 184-187
1991
ISSN/ISBN: 0253-9756 PMID: 1776487 Document Number: 319501
Pharmacokinetic profile was studied in 25 healthy fertile Chinese female volunteers after im norethindrone enanthate (NET-EN) 200 mg. The results were compared with the data from British women in our previous paper. Following a single im NET-EN 200 mg, the times to reach peak levels of NET-EN and NET were 4.0 .+-. 2.8 d and 5.4 .+-. 2.0 d, and their peak values were 5.0 .+-. 1.8 and 12.6 .+-. 0.9 ng .cntdot. ml-1, respectively. Mean elimination T 1/2 of NET was significantly longer than that of NET-EN. Mean apparent elimination T 1/2 were 14.8 .+-. 3.8 d for and 11.4 .+-. 5.7 d for NET-EN. The elimination rate of NET in Chinese women was significantly slower than that in British women. There was no significant ethnic difference in absorption kinetics of NET and NET-EN.