Pharmacokinetics and bioavailability of famotidine in 10 Chinese healthy volunteers
Gao, S.; Liu, G.L.; Wang, S.X.; Gao, X.H.
Zhongguo Yao Li Xue Bao 12(3): 195-198
1991
ISSN/ISBN: 0253-9756 PMID: 1781278 Document Number: 386516
The pharmacokinetics and bioavailability of famotidine were investigated by HPLC method in 10 Chinese healthy volunteers. Data obtained from HPLC were analysed automatically using a MCPKP program on microcomputer. Linear pharmacokinetics were observed following either iv or po administration. After 20 mg iv, plasma levels declined bioexponentially with an initial T1/2 of 0.3 .+-. 0.2 h and terminal T1/2 of 3.5 .+-. 0.8 h. The plasma elimination T1/2 following po administration were 3.4 .+-. 0.7 h and 3.5 .+-. 0.5 h for capsules and tablets respectively. Oral absorption was incomplete. The absolute bioavailabilities were 38 .+-. 10% for capsules and 43 .+-. 11% for tablets. Renal excretion was the major route of elimination. About 72% of the dose were recovered as unchanged famotidine in urine. Mean renal and plasma clearance were 416 and 541 ml .cntdot. min-1 respectively.