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Pharmacokinetics of cloprednol in healthy volunteers

Legler, U.F.

International Journal of Clinical Pharmacology Therapy and Toxicology 26(4): 173-175

1988

ISSN/ISBN: 0174-4879
PMID: 3403094
Document Number: 321948
Kinetic data for the synthetic corticoid cloprednol were determined in 8 healthy male volunteers after single oral doses (20 mg). Maximal plasma levels (Cmax) of 426 .+-. 116 ng/ml occurred within 101 .+-. 44 min after oral intake. Cloprednol plasma levels declined monoexponentially after oral administration. Total apparent plasma clearance was 4.07 .+-. 0.72 ml/min/kg and apparent clearance of unbound cloprednol was 9.75 .+-. 0.8 ml/min/kg. Plasma protein binding was 74 to 94%. Volume of distribution at steady-state was 0.81 .+-. 0.14 l/kg for total cloprednol and 1.99 .+-. 0.33 l/kg for unbound drug. The results presented in this study characterize the kinetics of total and unbound cloprednol for the first time.

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