Planning of samples for linkage analysis. Incomplete penetrance
Aksenovich, T.I.; Ginzburg, E.K.
Genetika 29(10): 1741-1749
1993
ISSN/ISBN: 0016-6758 PMID: 8307363 Document Number: 412133
Dependence of the minimal size of a pedigree sample providing the given quality of a linkage decision on the genotype penetrance of the localized gene is considered. The two ways of the sample informativity increase are discussed and their effects are estimated. These ways are: the adequate choice of a marker gene and certain complication of a pedigree structure. It is shown for the latter that the effect can be achieved only for certain phenotypic characteristics of the additional pedigree members.