The segregation-linkage analysis of genetically determined characters
Rozanski, B.S.; Pietrzyk, J.J.
Acta Anthropogenetica 9(1-3): 77-80
1985
ISSN/ISBN: 0258-0357 PMID: 3843750 Document Number: 257091
The model of combined segregation-linkage analysis is presented. The method offers the opportunity of simultaneous estimation of recombination fraction between the locus of genetic marker and that of a disease gene and the evaluation of its inheritance pattern. The computer programme MUBAS estimates combinations of parameters: dominance-d, penetrance-t and recombination fraction by the method of maximum likelihood using the distribution of the observed numbers of sib pairs: ill/proband and healthy/proband.