Phospholipid composition of erythrocytes in patients with chronic kidney failure
Akalaev, R.N.; Abidov, A.A.
Voprosy Meditsinskoi Khimii 39(5): 43-45
1993
ISSN/ISBN: 0042-8809 PMID: 8279143 Document Number: 411554
Qualitative and quantitative composition of lipid fractions was studied in erythrocytes of 221 patients (16-62 years old) in the terminal step of chronic renal failure. The following lipid fractions were studied: total phospholipids, monoglycerides, cholesterol, free fatty acids, diglycerides, triglycerides, methyl esters of fatty acids, cholesterol esters, lysophosphatidyl choline, phosphatidyl serine, lysophosphatidyl ethanolamine, sphingomyelin, phosphatidyl inositol, phosphatidyl choline, lysocardiolipin, phosphatidyl ethanolamine, cardiolipin, lysophosphatidic acid and phosphatidic acid. The alterations observed in the phospholipid composition of erythrocyte membranes appear to occur due to intracellular transformations related to specific metabolism in uremia. These alterations of phospholipid composition in erythrocyte membranes of patients with chronic renal failure, which were found to be intoxication-dependent, may be used in prognostic evaluation of patients' state under conditions of uremia development.