Attenuation and reversion of the Sabin vaccine strains of poliovirus

Minor, P.D.

Developments in Biological Standardization 78: 17-26

1993


ISSN/ISBN: 0301-5149
PMID: 8388828
Document Number: 411383
Studies of the molecular basis of the attenuation and reversion of the attenuated phenotype of the Sabin vaccine strains suggest that few mutations are involved. It is striking that mutations in the 5' non-coding region within a 10 base region implicated in a base pair structure have been identified in all the Sabin vaccine strains. The mutations have effects on in vitro phenotypes which have implications for the production of vaccines.

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