Use of metyrapone to treat pituitary-dependent hyperadrenocorticism in a cat with large cutaneous wounds
Daley, C.A.; Zerbe, C.A.; Schick, R.O.; Powers, R.D.
Journal of the American Veterinary Medical Association 202(6): 956-960
1993
ISSN/ISBN: 0003-1488 PMID: 8468223 Document Number: 411363
Metyrapone, a drug that inhibits cortisol production, was used to lower plasma cortisol concentration and alleviate skin lesions caused by pituitary-dependent hyper-adrenocorticism in a cat. Plasma cortisol concentration was documented by ACTH stimulation test results. During metyrapone treatment, alopecia, thin skin, and large cutaneous wounds resolved. Metyrapone was administered orally at a dosage of 65 mg/kg of body weight, every 12 hours. Metyrapone may be used in conjunction with surgery in the management of pituitary-dependent hyperadrenocorticism in cats.