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Growth factor-mediated combination therapy to treat large local human alveolar ridge defects

Nevins, M.; Camelo, M.; Nevins, M.L.; Ho, D.K.; Schupbach, P.; Kim, D.M.

International Journal of Periodontics and Restorative Dentistry 32(3): 263-271

2012

ISSN/ISBN: 1945-3388
PMID: 22408770
Document Number: 657601
The purpose of this case report is to demonstrate the effectiveness of a matrix consisting of recombinant human platelet-derived growth factor BB (rhPDGF-BB)-hydrated cancellous allogenic block graft in the reconstruction of large local human alveolar ridge defects. The results suggest improved bone regeneration when combining rhPDGF-BB with the allogenic block graft. The clinical and histologic evidence of new bone formation as well as bone remodeling supports the clinical potency of this growth factor-mediated therapy.

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