Remission of pituitary-dependent Cushing's disease after removal of nonneoplastyic pituitary gland
Taylor, H.C.; Velasco, M.E.; Brodkey, J.S.
Archives of Internal Medicine 140(10): 1366-1368
1980
ISSN/ISBN: 0003-9926 PMID: 6252859 Document Number: 162042
Transsphenoidal hypophysectomy was performed on a 28 yr old woman with pituitary-dependent Cushing's disease. Both clinical and chemical resolution of the hypercortisolism was achieved in spite of no evident pituitary microadenoma or cell hyperplasia. Histologic examination revealed widespread Crooke's changes and normal relative numbers, size and distribution of corticotrophs. Rare patients with pituitary-dependent Cushing's disease may have excessive pituitary production of ACTH in the absence of an adenoma or corticotroph cell hyperplasia.