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Effects of methylflavonolamine on TXA2 and PGI2 plasma levels in rabbits with myocardial infarction

Zhang, P.; Tang, Y.Z.; Hao, Y.B.; Tao, R.

Zhongguo Yao Li Xue Bao 14(3): 266-268

1993

ISSN/ISBN: 0253-9756
PMID: 8237408
Document Number: 409121
Effects of methylflavonolamine (MFA) on TXA-2 and PGI-2 plasma levels in rabbits of myocardial infarction were investigated. It was found that TXB-2 levels were inhibited by MFA 2.5 or 5.0 mg cntdot kg-1 iv while 6-keto-PGF-1alpha levels were only slightly inhibited after repeated doses of 5.0 mg cntdot kg-1 iv within 6 h. This result indicates that MFA exhibit stronger inhibition on cyclo-oxygenase in platelets than in endothelial cells. In addition, the myocardial injury and the size of myocardial infarction were much less in the MFA treated groups than in the control.

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