Serum interleukin-2 receptor levels in Hodgkin disease and other solid tumors of childhood
Pui, C.H.; Hudson, M.; Luo, X.; Wilimas, J.; Evans, W.; Crist, W.M.
Leukemia 7(8): 1242-1244
1993
ISSN/ISBN: 0887-6924 PMID: 8394483 Document Number: 408646
Serum levels of interleukin-2 receptor (IL2R) were determined in children with newly diagnosed Hodgkin disease (n = 68), Wilms tumor (n = 20), osteosarcoma (n = 18), rhabdomyosarcoma (n = 18), or Ewing sarcoma (n = 15). Measurements of soluble IL2R were positively correlated with disease stage in Hodgkin disease but not in other tumors. Very high levels of soluble IL2R (> or = 5000 U/ml) were significantly associated with a poorer treatment outcome in Hodgkin disease (p = 0.006) and retained significance in a multivariate analysis (p = 0.03). The addition of soluble IL2R measurements to existing prognostic models may improve risk assignment in children with Hodgkin disease.