Intraindividual comparison of haloperidol decanoate and oxyprothepine in maintenance therapy in schizophrenic psychoses
Cesková, E.; Svestka, J.; Rysánek, R.
Ceskoslovenska Psychiatrie 89(1): 11-14
1993
ISSN/ISBN: 0069-2336 PMID: 8099534 Document Number: 407456
In an open intraindividual comparison of haloperidol and oxyprothepine decanoates there was a tendency in favour of haloperidol decanoate. At the end of 9 months' maintenance treatment there were no statistically significant differences in the global BPRS score, CGI and individual BPRS items with exception of paranoidity. No differences in the occurrence of rehospitalizations and ambulatory relapses were found. As for side effects with haloperidol decanoate a higher occurrence of akathisia and a lower mean weigh increase (2 kg v. 4 kg) were observed and twice more pts had no side effects in comparison with oxyprothepine decanoate, but also these differences were not statistically significant. Taking into consideration the differences found (even if not statistically significant) and the individual reactivity, it seems to us advantageous to have a broader choice of depot neuroleptics.