Biological determinants of schizophrenic psychoses
Verhoeven, W.M.; Westenberg, H.G.; Van Ree, J.M.
L'Encephale 10(2): 53-68
1984
ISSN/ISBN: 0013-7006 PMID: 6088215 Document Number: 240732
In this article the biological factors i.e. neuropathological/structural and biochemical, involved in the pathogenesis of schizophrenia are reviewed. Particularly the endorphin hypothesis, which states that disturbances in the fragmentation of beta-endorphin are implicated in schizophrenia, is emphasized. The concept of type I and type II schizophrenia, disturbances in the serine-glycine metabolism and the neuropeptide strategy are currently under investigation.