Husbandry factors and the prevalence of age-related amyloidosis in mice
Lipman, R.D.; Gaillard, E.T.; Harrison, D.E.; Bronson, R.T.
Laboratory Animal Science 43(5): 439-444
1993
ISSN/ISBN: 0023-6764 PMID: 8277723 Document Number: 405911
A retrospective study of the prevalence of amyloidosis in mice from several facilities was done. Amyloid deposition is an age-related lesion. The influence of common laboratory factors on the occurrence of this lesion was analyzed. This study demonstrated genotypic difference in susceptibility to amyloidosis and showed that caging and pathogen status both impact on the number of cases of amyloidosis seen in a population. The lowest percentage of affected mice was seen when the animals were individually caged in a specific pathogen-free facility where conditions of series were minimized.