Fibromyalgia prevalence and related factors in a large registry of patients with systemic lupus erythematosus
Torrente-Segarra, V.ç; Salman-Monte, T.C.; Rúa-Figueroa, Íñi.; Pérez-Vicente, S.; López-Longo, F.J.; Galindo-Izquierdo, M.ía.; Calvo-Alén, J.; Olivé-Marqués, A.; Ibañez-Ruán, J.; Horcada, L.; Sánchez-Atrio, A.; Montilla, C.; Rodríguez-Gómez, M.; Díez-Álvarez, E.; Martinez-Taboada, V.; Andreu, J.é L.; Fernández-Berrizbeitia, O.; Hernández-Beriain, J.é A.; Gantes, M.; Hernández-Cruz, B.; Pecondón-Español, Án.; Marras, C.; Bonilla, G.; Pego-Reigosa, J.é M.; Blanco, R.; Vel
Clinical and Experimental Rheumatology 34(2 Suppl 96: S40-S47
2016
ISSN/ISBN: 0392-856X PMID: 26575317 Document Number: 688319
The objective of this study is to determine the prevalence of fibromyalgia (FM) in systemic lupus erythematosus (SLE) patients and to study its relationship to depression and other SLE-related factors. A cross-sectional data analysis from the RELESSER-Transversal Spanish Registry, which includes SLE patients in a national multicentre retrospective charts review, was performed. patients who fulfilled ≥4 ACR 1997 SLE criteria. Main variables were disease duration, depression, sociodemographics, comorbidities, SLE activity symptoms, serological findings, therapies and different disease status indices. Statistical analyses included a descriptive, associative and logistic regression analyses. A literature review was performed. 3,591 SLE patients were included, 90.1% women, 34.6 years of age at diagnosis (SD 14.6 years) and 93.1% Caucasians. FM prevalence was 6.2%. SLE patients with disease duration >5 years showed more FM than those with duration <5 years: 6.9% vs. 4.0%, respectively (p<0.05). SLE-FM patients showed higher prevalence of depression compared to non-FM-SLE patients: 53.1% vs. 14.6%, respectively (p<0.001). After adjusting by risk factors, the OR (CI) of suffering depression in FM-SLE patients was 6.779 (4.770-9.636), p<0.001. The OR of having secondary Sjögren's 2.447 (1.662-3.604), p<0.001, photosensitivity 2.184 (1.431-3.334), p<0.001, and oral ulcers 1.436 (1.005-2.051), p=0.047. Prevalence of FM in Caucasian SLE patients was high compared to the general population, and was significantly higher in those in later stages of disease. SLE patients with depression showed a strong risk of developing FM. Photosensitivity, oral ulcers and secondary Sjögren's were the only SLE-related factors associated with FM.