Effect of phosphatidylcholine cholesterol liposomes on the growth of bacterial cultures
Mel'iantseva, L.P.; Kreĭnes, V.M.; Mel'nikova, V.M.; Gladshteĭn, A.I.
Antibiotiki i Khimioterapiia 37(1): 14-17
1992
ISSN/ISBN: 0235-2990 PMID: 1530351 Document Number: 405128
The in vitro studies showed that incubation of S. aureus, P. aeruginosa, E. coli and P. mirabilis in the presence of phosphatidyl choline cholesterol liposomal suspension was accompanied by inhibited microbial growth. The effect was time- and dose-dependent. The arranged structure of the liposomal membranes played an important role in genesis of the bactericidal action of the liposomes since the use of lipids of the same composition in a nonpolysomal form markedly lowered the bactericidal effect.