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Effects of pesticide fluometuron (cotoran) on template synthesis of RNA

Khamidov, D.K.; Mirakhmedov, A.K.; Sagatova, G.A.; Azimova, S.S.

Biulleten' Eksperimental'noi Biologii i Meditsiny 113(3): 261-263

1992

ISSN/ISBN: 0365-9615
PMID: 1384777
Document Number: 404923
The experiments on the investigation of pesticide fluometuron (cotoran) influence on nuclease sensitivity and template activity of rat liver chromatin were carried out. Cotoran was found to bind specifically with non-histone proteins of chromatin. It was shown that this pesticide considerably decreases template activity of chromatin and its sensitivity to the action of nucleases. It suggests, that certain conformation changes occur in chromatin upon the action of cotoran.

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