Polypeptides p14 and p31 of the African swine fever virus--early proteins located on the membrane of the infected cell
Kolontsov, A.A.; Ustin, A.V.; Shubina, N.G.; Piria, A.A.; Makarov, V.V.
Voprosy Virusologii 37(3): 165-168
1992
ISSN/ISBN: 0507-4088 PMID: 1441444 Document Number: 404847
African swine fever virus polypeptides p14 and p31 are synthesized in the presence of phosphonacetic acid which inhibits viral DNA replication, and therefore they are early viral proteins. These polypeptides were found to be localized on plasma membranes by immunofluorescence with monospecific antisera and monoclonal antibodies and by selective solubilization of infected cells. The p14-specific antibodies mediate complement-dependent cytolysis and antibody-dependent cytotoxicity of the cells infected with African swine fever virus.