The formation and enzymatic repair of DNA modifications caused by the haloethylnitrosoureas and related compounds
Ludlum, D.B.; Habraken, Y.; Carter, C.A.; Matijasevic, Z.
Nucleic Acids Symposium Series 27: 25-26
1992
ISSN/ISBN: 0261-3166 PMID: 1289818 Document Number: 404296
The haloethylnitrosoureas are both useful antitumor agents and known carcinogens. These biological activities are believed to be associated with DNA modification, and some biologically significant lesions have been identified in DNA exposed to these agents. At the same time, DNA repair is a cause of resistance to treatment by these agents, and may also serve as protection against their carcinogenic effects.