Pharmacokinetics of gentamicin after intratracheal administration in tracheotomy patients
Gu, C.N.; Shan, H.W.; Deng, Y.L.; Zhu, C.J.; Ding, X.H.; Gu, Q.P.
Zhongguo Yao Li Xue Bao 13(4): 375-376
1992
ISSN/ISBN: 0253-9756 PMID: 1456066 Document Number: 403146
Seventeen tracheotomy patients were given gentamicin (Gen) into trachea at the dosage of 2 and 4 mg .cntdot. kg-1. Gen concentration in serum was determined by fluorescence polarization immunoassay. Pharmacokinetic parameters were calculated by micro-computer pharmacoketic program (MCPKP). T1/2ka, Tp, and Cmax were 0.6 .+-. 0.3 h. 1.7 .+-. 0.7 h, and 4.6 .+-. 1.8 .mu.g .cntdot. ml-1, respectively in 4 mg .cntdot. kg-1 group and 0.3 .+-. 0.3 h, 0.9 .+-. 0.5 h, and 0.4 .+-. 0.2 .mu.g .cntdot. m-1, respectively in 2 mg .cntdot. kg-1 group (P < 0.05). T1/2kel was 30 .+-. 11 h in patients of serum creatine (Cr) > 2 mg% and 6 .+-. 5 h in patients of Cr < 2 mg% (P < 0.01). No significant difference could be found between Cmax of different renal function patients (P > 0.05).