Pharmacokinetics of gentamicin after its regional endolymphatic and lymphotropic administration to dogs
Buianov, V.M.; Danilov, K.Iu.; Brodinova, N.S.; Khritonov, S.V.; Zaranko, E.I.
Antibiotiki i Khimioterapiia 36(1): 32-34
1991
ISSN/ISBN: 0235-2990 PMID: 2053820 Document Number: 370886
It was shown that intranodular inguinal administration of gentamicin provided its high concentrations in central lymph, blood and paraaortal lymph nodes and increased the antibiotic levels in the abdominal organs 2.33 to 6.66 times as compared with its intramuscular administration while lymphotropic retroperitoneal administration of gentamicin provided more prolonged maintenance of the antibiotic therapeutic concentrations in lymph of the thoracic lymphatic duct, central blood, paraaortal lymph nodes and the abdominal organs in comparison to its intramuscular administration. Intranodular inguinal administration of drugs providing the highest concentrations in all the organs of the abdominal cavity and the ways of the infection penetration is useful in therapy of severe inflammatory diseases of the abdominal organs inclined to generalization and lymphotropic retroperitoneal administration of drugs is useful in therapy of less severe purulent inflammatory processes in the abdominal cavity.