Distribution of exogenous interferon in experimental animals following intratracheal administration
Fedorova, I.B.; Nekliudova, L.I.
Voprosy Virusologii 4: 416-418
1975
ISSN/ISBN: 0507-4088 PMID: 1216832 Document Number: 86615
The distribution of homologous and heterologous interferon in rabbits after intratracheal administration was studied. The content of interferon in the lung tissue decreased 1 hour after injection. At 3 hours the interferon concentration in the lungs in some animals decreased 2-10-fold as compared with the initial. A considerable reduction in interferon content in the lungs was observed 24 hours post-injection. In the blood serum interferon was found in low titers 1, 3 and 6 hours after intratracheal injection. On the contrary, the amount of interferon in the urine increased beginning at 3-6 hours after injection and up to 24-48 hours.