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Preclinical study of the general toxic effect of polyplatillen

Shalimov, S.A.; Keĭsevich, L.V.; Trokhimenko, E.P.; Dziublik, I.V.; Volchenskova, I.I.

Klinicheskaia Khirurgiia 6: 15-17

1992

ISSN/ISBN: 0023-2130
PMID: 1453616
Document Number: 403050
Toxic action of polyplatillen, a principally new platinum compound, was studied on laboratory animals and cell culture. When compared with cis-dichlorodiamminplatinum, the preparation is 10-fold less toxic in animals and 100-fold--in the cellular systems. Reversibility of damaging action of polyplatillen at "non-toxic" dosages conditions the perspectiveness of its further clinical trials.

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