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Bifurcation analysis of a mathematical model of the interaction of cytotoxic lymphocytes with tumor cells. the effect of immunologic amplification of tumor growth and its interconnection with other "anomolous" phenomena of oncoimmunology

Kuznetsov, V.A.; Makalkin, I.A.

Biofizika 37(6): 1063-1070

1992

ISSN/ISBN: 0006-3029
PMID: 1298347
Document Number: 402799
Mathematical model of the immune response of the cytotoxic lymphocytes to the nonexponentially growing immunogenic tumour has been studied. Local and global biffurcations for realistic values of the parameters were determined. The connection of the oncoimmunological "anomalous" phenomena (immunostimulation of tumour growth, "sneaking through" of tumour, formation of the tumour "dormant" state) has been shown. The probability of manifestation of these effects in vivo was estimated.

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Shinomiya, Y.; Harada, M.; Tamada, K.; Kurosawa, S.; Okamoto, T.; Terao, H.; Takenoyama, M.; Ito, O.; Hirashima, C.; Li, T.; Shirakusa, T.; Nomoto, K. 1997: The augmenting effect of OK432-stimulated B cells on the in vitro generation of anti-tumor cytotoxic T lymphocytes from tumor-draining lymph node cells: the possible role of interleukin-12 In Vivo 11(1): 1-8
Gillies, S.D.; Wesolowski, J.S.; Lo, K.M. 1991: Targeting human cytotoxic T lymphocytes to kill heterologous epidermal growth factor receptor-bearing tumor cells. Tumor-infiltrating lymphocyte/hormone receptor/recombinant antibody Journal of Immunology 146(3): 1067-1071
Steiner, T.; Junker, U.; Wunderlich, H.; Schubert, J. 1999: Are renal cell carcinoma cells able to modulate the cytotoxic effect of tumor infiltrating lymphocytes by secretion of interleukin-6? Anticancer Research 19(2c): 1533-1536
Li, Q.; Zhang, Y.; Chen, X.-h.; Cao, W.-x.; Gu, Q.-l.; Zhu, Z.-g.; Liu, B.-y. 2006: Immunotherapeutic efficacy of both helper T lymphocytes and cytotoxic T lymphocytes epitopes augmented dendritic cells tumor vaccine on gastric cancer Zhonghua Wei Chang Wai Ke Za Zhi 9(2): 148-151
Kolobov, A.V.; Kuznetsov, M.B. 2015: Investigation of the Influence of Angiogenesis on Tumor Growth with the use of a Mathematical Model Biofizika 60(3): 555-563
Hoshino, T.; Jiang, Y.Z.; Dunn, D.; Paul, D.; Qazilbash, M.; Cowan, K.; Wang, J.; Barrett, J.; Liu, J. 1998: Transfection of interleukin-12 cDNAs into tumor cells induces cytotoxic immune responses against native tumor: implications for tumor vaccination Cancer Gene Therapy 5(3): 150-157
Kunicka, J.E.; Fox, F.E.; Seki, H.; Oleszak, E.L.; Platsoucas, C.D. 1991: Hybridoma-derived human suppressor factors: inhibition of growth of tumor cell lines and effect on cytotoxic cells Human Antibodies and Hybridomas 2(3): 160-169
Peiper, M.; Goedegebuure, P.S.; Eberlein, T.J.; Zornig, C. 1997: Cytotoxic T-lymphocytes and the recognition of tumor antigens--an approach to "preventive tumor vaccination?" Zentralblatt für Chirurgie 122(3): 141-148
Frost, P.; Rose, N.R. 1978: In vitro induction of lymphoblasts and cytotoxic lymphocytes with prostate tumor cells National Cancer Institute Monograph 1978(49): 169-172
Miki, S.; Ksander, B.; Streilein, J.W. 1992: Studies on the minimum requirements for in vitro "cure" of tumor cells by cytotoxic T lymphocytes Regional Immunology 4(6): 352-362
Wongkajornsilp, A.; Ouyprasertkul, M.; Sangruchi, T.; Huabprasert, S.; Pan, Y.; Tisavipat, N.; Chanyavanich, V.; Sangruchi, S.; Chomsamut, K.; Anthony, D.D. 2001: The analysis of peri-tumor necrosis following the subcutaneous implantation of autologous tumor cells transfected with an episome transcribing an antisense insulin-like growth factor 1 RNA in a glioblastoma multiforme subject Journal of the Medical Association of Thailand 84(Suppl 3): S740-S747
Thiele, D.L.; Lipsky, P.E. 1986: Leu-Leu-OMe sensitivity of human activated killer cells: delineation of a distinct class of cytotoxic T lymphocytes capable of lysing tumor targets Journal of Immunology 137(4): 1399-1406
Pagliacci, M.C.; Fumi, G.; Migliorati, G.; Grignani, F.; Riccardi, C.; Nicoletti, I. 1993: Cytostatic and cytotoxic effects of tumor necrosis factor alpha on MCF-7 human breast tumor cells are differently inhibited by glucocorticoid hormones Lymphokine and Cytokine Research 12(6): 439-447
Bernstein, I.D.; Wright, P.W.; Cohen, E. 1976: Generation of cytotoxic lymphocytes in vitro: response of immune rat spleen cells to a syngeneic gross virus-induced lymphoma in mixed lymphocyte-tumor culture Journal of Immunology 116(5): 1367-1372
Volarevic, V.; Milovanovic, M.; Djekovic, A.; Petrovic, B.; Arsenijevic, N.; Bugarcic, Z.D. 2010: The cytotoxic effects of some selected gold(III) complexes on 4T1 cells and their role in the prevention of breast tumor growth in BALB/c mice Journal of BUON: Official Journal of the Balkan Union of Oncology 15(4): 768-773
Fuks, B.B.; Zedginidze, M.S.; Spirande, I.V.; Kogarko, I.N.; Sterlina, A.G. 1981: Detection of the cytotoxic effect of tumor cells against the targets of normal killers Biulleten' Eksperimental'noi Biologii i Meditsiny 92(9): 342-345
Ohnishi, K.; Bonavida, B. 1987: RCS tumor-host interactions: tumor growth dependence on L3T4+ T cells and its regulation by suppressor cells Progress in Clinical and Biological Research 244: 359-368
Choudhary, A.; Davodeau, F.; Moreau, A.; Peyrat, M.A.; Bonneville, M.; Jotereau, F. 1995: Selective lysis of autologous tumor cells by recurrent gamma delta tumor-infiltrating lymphocytes from renal carcinoma Journal of Immunology 154(8): 3932-3940
Nagao, N.; Katoh, M.; Kumazawa, I.; Tomita, H.; Sugiyama, Y.; Kunieda, K.; Miya, K.; Saji, S. 1999: A recurrent case of esophageal cancer in which metastatic skin tumor disappeared after local injection of activated lymphocytes with tumor-pulsed dendritic cells Gan to Kagaku Ryoho. Cancer and ChemoTherapy 26(12): 1937-1939
Cerottini, J.C.; Brunner, K.T. 1972: Cytotoxic lymphocytes and anti-tumor immunity Annales de l'Institut Pasteur 122(4): 659-668