Thermogenesis, brown adipose tissue and dexfenfluramine in animal studies
Rothwell, N.J.; Le Feuvre, R.A.
International Journal of Obesity and Related Metabolic Disorders Journal of the International Association for the Study of Obesity 16(Suppl 3): S67-S71
1992
ISSN/ISBN: 0307-0565 PMID: 1338325 Document Number: 402625
D-Fenfluramine is a potent stimulator of thermogenesis in the rat, an action which may contribute to its effects on body weight. The actions of D-fenfluramine appear to control release of endogenous 5-HT which subsequently induces release of eicosanoids and corticotrophin-releasing factor. Peripheral heat production results mainly from sympathetic activation of thermogenesis.