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Brown adipose tissue in Duchenne's progressive muscular dystrophy

Ito, M.; Sekine, I.; Fujii, H.; Ogawa, M.

Archives of Pathology and Laboratory Medicine 112(5): 550-552

1988

ISSN/ISBN: 0003-9985
PMID: 3358657
Document Number: 316247
Both granular and multilocular periadrenal brown adipose tissue (BAT) was present in 16 patients with Duchenne's progressive muscular dystropy (PMD). In 12 cases (75%), diffusely distributed periadrenal BAT was observed. The common cause of death was respiratory failure, and blood gas level showed marked hypoxia. Scattered myocardial fibrosis was seen in all cases of PMD. We suspected that chronic hypoxia and cardiac fibrosis might be largely responsible for BAT transformation in patients with PMD.

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