Regulation of respiratory activity of brown adipose tissue mitochondria through changes in cytochromes
Gaikwad, A.; Ramasarma, T.; Kurup, C.K.
Biotechnology and Applied Biochemistry 12(5): 562-566
1990
ISSN/ISBN: 0885-4513 PMID: 2288713 Document Number: 352392
Exposure of cold-acclimatized rats to heat (37 degrees C) for a short period decreased brown adipose tissue (BAT) mitochondrial substrate-dependent oxygen uptake and H2O2 generation. Both the concentration and substrate-dependent rate of cytochrome b reduction decreased as early as 3 h of heat exposure. These results identify cytochrome b as the locus of regulation of electron transport in BAT mitochondria under conditions of heat stress.