Effects of systemically-administered beta-casomorphin-7 on nociception in rats
Dubynin, V.A.; Maklakova, A.S.; Nezavibat'ko, V.N.; Alfeeva, L.A.; Kamenskiĭ, A.A.; Ashmarin, I.P.
Biulleten' Eksperimental'noi Biologii i Meditsiny 114(9): 284-286
1992
ISSN/ISBN: 0365-9615 PMID: 1477360 Document Number: 402567
The influence of food-derived heptapeptide beta-casomorphin-7 (beta-CM-7) on pain sensibility of white rats was studied by tail flick test. As shown for doses 10 and 20 mg/kg intraperitoneally, injected beta-CM-7 induced significant analgesia; lower peptide concentration (5 mg/kg) was ineffective. As a whole, there is a significant positive correlation between the intensity of analgesia and the quantity of administered exorphine. These changes of pain sensibility were observed for one hour after injection of heptapeptide; further measurements showed no significant difference of time reaction between control and experimental groups of rats. It was found out that animals with high native level of pain sensibility (4-8 sec) made the main contribution to manifestation of analgesia.