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Effects of barbital and disulfiram on the metabolism of intracerebroventricularly administered [14C]-5-hydroxytryptamine in rats

Fukumori, R.; Minegishi, A.; Satoh, T.; Kitagawa, H.; Yanaura, S.

Research Communications in Chemical Pathology and Pharmacology 26(1): 217-220

1979

ISSN/ISBN: 0034-5164
PMID: 515504
Document Number: 144266
Effects of barbital and disulfiram on the metabolism of serotonin (5-HT) in vivo were studied. One hr after intracerebroventricular injection of [14C]-5-HT (3 nmoles, 0.5 muCi), the levels of the total and deaminated radioactive materials were increased in rats receiving either barbital or disulfiram, as compared to those of control rats. In addition, an additive effect was observed by a combined administration of these two drugs. The results in this paper strongly suggest that barbital and disulfiram inhibit the metabolism of 5-hydroxyindoleacetaldehyde (5-HIAAld), a first deaminated metabolite in 5-HT metabolism.

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Bhattacharya, S.K.; Parmar, S.S. 1985: Antinociceptive effect of intracerebroventricularly administered histamine in rats Research Communications in Chemical Pathology and Pharmacology 49(1): 125-136
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Julkunen, R.J.; Airaksinen, M.M.; Puro, K. 1970: Effects of reserpine and 5-hydroxytryptamine on the secretion of mucopolysaccharides in gastric juice of rats Annales Medicinae Experimentalis et Biologiae Fenniae 48(3): 149-154
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Hollenbach, K.; Pintye-Hódi, K.; Kedvessy, G. 1980: On the Polymorphism of barbiturates in powders and tablets. Part 4: the dissolution of barbital B and barbital a (modifications i and IIi and their release from tablets Die Pharmazie 35(1): 32-35
Wright, J.W.; Sullivan, M.J.; Quirk, W.S.; Batt, C.M.; Harding, J.W. 1986: Heightened pressor effect and dipsogenicity to intracerebroventricularly applied angiotensin II and III in spontaneously hypertensive rats Journal of Hypertension. Supplement: Official Journal of the International Society of Hypertension 4(6): S408-S411
Jørgensen, K.D. 1987: Comparison of the pharmacological properties of pituitary and biosynthetic human growth hormone. Demonstration of antinatriuretic/antidiuretic and barbital sleep effects of human growth hormone in rats Acta Endocrinologica 114(1): 124-131
Dubynin, V.A.; Maklakova, A.S.; Nezavibat'ko, V.N.; Alfeeva, L.A.; Kamenskiĭ, A.A.; Ashmarin, I.P. 1992: Effects of systemically-administered beta-casomorphin-7 on nociception in rats Biulleten' Eksperimental'noi Biologii i Meditsiny 114(9): 284-286
Sindgi, S.B.; Rao, M.A. 1973: Inhibition of ovarian compensatory hypertrophy by barbital sodium in hemispayed albino rats Current Science 42(5): 173-174
Qin, Y.-j.; Zeng, Y.-s.; Zhou, C.-c.; Li, Y.; Zhong, Z.-q. 2008: Effects of Rhodiola rosea on level of 5-hydroxytryptamine, cell proliferation and differentiation, and number of neuron in cerebral hippocampus of rats with depression induced by chronic mild stress Zhongguo Zhong Yao Za Zhi 33(23): 2842-2846
Absava, G.I.; Artemenko, G.N.; von Littrow, K.; Vikhliaev, I.I. 1975: Correlation between the distribution of triftazin in certain organs of rats and its pharmacological effects when administered by different methods Farmakologiia i Toksikologiia 38(3): 277-281
Pauli, J.R.; Gomes, R.J.; Luciano, E. 2006: Hypothalamo-pituitary axis: effects of physical training in rats administered with dexamethasone Revista de Neurologia 42(6): 325-331
Nelson, B.K.; Brightwell, W.S.; Burg, J.R. 1985: Comparison of behavioral teratogenic effects of ethanol and n-propanol administered by inhalation to rats Neurobehavioral Toxicology and Teratology 7(6): 779-783
Reigel, C.E.; Bourn, W.M. 1994: Cross-substitution of diazepam for barbital results in only a low incidence of audiogenic seizures upon withdrawal in dependent rats Proceedings of the Western Pharmacology Society 37: 137-140
Toy, P.; Hatfield, S.; Bull, R.; Couri, D. 1978: The effects of different levels of selenium administered to rats in drinking water on distribution and glutathione peroxidase Research Communications in Chemical Pathology and Pharmacology 21(1): 115-131
Aschkenasy, A. 1970: A comparative study of the hematological and tissue effects of testosterone administered to male rats by percutaneous or by subcutaneous routes Therapie 25(6): 1025-1046
Zhang, Z.; Huynh, H.; Teel, R.W. 1997: Effects of orally administered capsaicin, the principal component of capsicum fruits, on the in vitro metabolism of the tobacco-specific nitrosamine NNK in hamster lung and liver microsomes Anticancer Research 17(2a): 1093-1098