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Ultrastructure of the rat posterior pituitary gland, with special reference to the release mechanism of the neurosecretory substance

Kurosumi, K.

Medical Journal of Osaka University 21(2): 53-73

1971

ISSN/ISBN: 0030-6169
PMID: 5140281
Document Number: 40227
A detailed study of the ultrastructure of the posterior lobe of the pituitary was made in the normal and dehydrated rat, to clarify the mode of release of posterior pituitary hormones and the role of synaptic vesicles and pituicytes in this process. The nerve endings in the normal state contained neurosecretory granules (diam. 170 nm) and synaptic vesicles (diam. 50 nm). After dehydration, the number of synaptic vesicles increased and elongated profiles consisting of flattened sacs appeared in some nerve terminals; these were probably collapsed membranes which encase the neurosecretory granule in the normal state. No evidence was found for discharge of neurosecretory material by exocytosis. 2 types of pituicytes, protoplasmic and reticular, were observed; both contained lysozymes but lipid droplets occurred only in protoplasmic pituicytes. After dehydration, lipid droplets increased and pinocytotic vesicles appeared on the surface of the pituicytes. Possibly liquified lipoprotein from neurosecretory granule membranes is pinocytosed into the protoplasmic pituicyte and digested by lysozomes, and non-digestible lipid fuses to form large lipid droplets.

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