The fibrin glue system in the care of experimental injuries of the spleen and liver
Havlícek, K.; Vlcek, B.
Rozhledy V Chirurgii Mesicnik Ceskoslovenske Chirurgicke Spolecnosti 71(6): 320-327
1992
ISSN/ISBN: 0035-9351 PMID: 1509318 Document Number: 401668
In experiments on 28 rabbits and 28 baby pigs the authors tested the effectiveness of a fibrin glue mixture prepared from locally available components in a fatal injury of the liver and spleen. The authors used an original system of application "Duplojekt" for simultaneous application. Using the technique of digital compression of the margins of the wound and simple application of the fibrin glue, they repaired extensive tissue injury. They investigated the time needed for haemostasis, for adequate adherence of the coagulum to the wound and adequate hardness of the coagulum. They recorded the total time of the operation and amound of glue used. They used two different concentrations of fibrinogen with a low and high value and a standard concentration of thrombin for rapid reaction and formation of the coagulum. The authors found equal haemostatic effects of the two systems and different times of the mixtures with a high and low fibrinogen value. The glue with the high fibrinogen concentration was more effective. Both systems with the low and high fibrinogen concentration are, however, effective and reliable. Treatment of an extensive injury was safe in all instances. All experimental animals survived the operation, and the postoperative period and were killed at the defined times. The selected method and elaborated technique are useful for clinical surgery.