Effects of alpha-interferon on the level of adenosine metabolism enzymes and bactericidal activity of macrophages in staphylococcal infection
Lazarenko, L.N.; Spivak, N.I.; Umanskiĭ, V.I.; Vikhot', N.E.; Ivanenko, V.K.
Biulleten' Eksperimental'noi Biologii i Meditsiny 114(7): 63-66
1992
ISSN/ISBN: 0365-9615 PMID: 1421314 Document Number: 401009
In staphylococcal infection the changes in functional ability of macrophages occur: their oxygen-depending bactericidity and adenosine-desaminase activity are depressed 5-nucleotidase ability increases. Introduction of homologous alpha-IFN in the dose of 1 x 10(3) u/mouse leads to enhancing macrophage bactericidity of the animals infected, inhibits their 5-nucleotidase activity and enhances adenosine desaminase one. Influence of alpha-IFN on the activity of adenosine metabolism enzymes in macrophages can be considered one of the most important mechanisms of its modulating effect in bacterial infections.