Prognostication of chronic Ph+ myeloid leukemia using the PHCML.EXE computer program
Berger, J.; Chrobák, L.; Voglová, J.; Steruská, M.
Vnitrni Lekarstvi 38(2): 160-165
1992
ISSN/ISBN: 0042-773X PMID: 1595204 Document Number: 400513
In 193 patients with Ph-positive chronic myeloid leukaemia (CML) Sokal's calculation formulae prognosticating initial risk status were applied, using the computer program PHCML. The aim of this study was to the prognostic reproducibility of these prognostic staging systems in our patient population. Our results confirm the previous conclusions that prognostic discrimination is possible at the time of diagnosis of CML but in our patients with poorer prognosis the stratification seems to be more accurate. No significant advantage was achieved when we prognosticated our patients younger than 46 years using the formula recommended by Sokal et al. specifically for younger patients. We analyzed different criteria when segregating patients in groups with better or poorer prognosis. We found that the coefficient of the patient's relative risk as the boundary, was 1.9 our patient's group contrary to 1.2 in Sokal's studies.