Hypoglycemic activity of bicyclic diterpenoids of the clerodane series as compared to adebit and maninil
Tashmukhamedova, M.A.; Mukhina, O.A.; Syrov, V.N.; Khushbaktova, Z.A.; Katkova, S.P.; Kosovskiĭ, M.I.
Problemy Endokrinologii 38(1): 48-50
1992
ISSN/ISBN: 0375-9660 PMID: 1308597 Document Number: 400175
Biocyclic diterpenoids--salvin, salvicin and salvifolin, administered per os to rats at a dose of 50 mg/kg show marked hypoglycemic activity in intact animals as well as in animals with experimental hyperglycemia developing against a background of GTT (3000 mg/kg intraperitoneally) or alloxan (150 mg/kg subcutaneously). They are superior to adebit but inferior to maninil. Prophylactic and therapeutic administration of these compounds ensure the preservation of islet beta-cells in animals with alloxan diabetes.