Cyclopentenyl ethylamines active on CNS
Mulè, A.; Pirisino, G.; Moretti, M.D.; Sparatore, F.; Dimich, P.M.; Satta, M.; Peana, A.
Farmaco 47(9): 1161-1172
1992
ISSN/ISBN: 0014-827X PMID: 1300121 Document Number: 399792
Two new cyclopentenylethylamines were prepared and were submitted to a pharmacological screening together with some others previously described and now reprepared. All compounds exhibited different degrees of depressive activity on CNS and good analgesic activity. Compound 5, bearing a phenyl group on the carbon atom to which the amino group is connected, appears rather interesting being the most active as analgesic and the least toxic. Compounds 2 and 3 are able to antagonize in a certain degree lethal doses of physostigmine and also, respectively, of pentylenetetrazole and strychnine.
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