Immunomorphometric study of megakaryocytes in patients with myelodysplastic syndrome
Marisavljević, D.; Rolović, Z.
Srpski Arhiv Za Celokupno Lekarstvo 120(11-12): 317-320
1992
ISSN/ISBN: 0370-8179 PMID: 1340640 Document Number: 399791
The purpose of this study was to analyse, by immunomorphometry, megakaryocytopoiesis in patients with myelodysplatsic syndrome. The results revealed that, in spite of marked megakaryocyte hyperplasia, patients with myelodysplastic syndrome suffer from severe peripheral thrombocytopenia. Megakaryocytes in myelodisplastic syndrome have, in average, small cellular and nuclear diameter and 35.3% of them (s. c. micromegakaryocyres) can be identified only by using immunohistochemical technique. In conclusion, there is severe maturation disturbancy, ineffectiveness and disregulation of megakaryocytopoiesis in myelodysplastic syndrome.