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Disorders of hemostasis after polytrauma. on the extent of intrinsic fibrinolytic activity in the preclinical phase

Lampl, L.; Bock, K.H.; Hartel, W.; Helm, M.; Tisch, M.; Seifried, E.

Der Chirurg; Zeitschrift für Alle Gebiete der Operativen Medizen 63(4): 305-309

1992

ISSN/ISBN: 0009-4722
PMID: 1597093
Document Number: 398867
Coagulation disorders are of utmost importance in emergency surgery as well as for secondary organ failure of polytraumatized patients. In order to get hold of the early onset of these disorders, blood samples were harvested from 20 randomly selected patients (Injury Severity Score mean = 36.7 +/- 10.5) on the scene of emergency (mean = 18 [10-29] min after trauma) and at the time of hospital admission (mean = 78 [58-98] min after trauma). In addition to the activation of intravascular coagulation and the consumption of physiological inhibitors, high amounts (10- to 50-fold above normal) of degradation products (FgDP, FbDP, TDP, D-dimers) are present on the scene, already. The influence of hemodilution due to high-volume resuscitation is discussed.

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