Change in pulse pressure during the preclinical phase of preeclampsia
Adsumelli, R.S.N.; Elimian, A.; Wiencek, V.; Benveniste, H.D.; Glass, P.S.A.; Quirk, J.Gerald.
Journal of Reproductive Medicine 51(1): 26-30
2006
ISSN/ISBN: 0024-7758 PMID: 16482773 Document Number: 603851
OBJECTIVE; To measure and compare pulse pressure in early pregnancy between parturients who subsequently did or did not develop preeclampsia.STUDY DESIGN: Retrospective chart review of 44 parturients with preeclampsia and 187 controls without. in I he groups were compared for blood pressure indices be- elevated PP fore 15 weeks' gestation and gestational age other maternal variables.RESULTS: The preeclampsia group had a higher proportion of African Americans (23% vs. 9.6%, p = 0.005) and higher body mass index (26.2 +/- 7.1 SD vs. 24.0 +/- 4.9 kg/m(2), p = 0.03). Before 15 weeks' gestation, women who later developed preeclampsia had higher systolic (114.3 +/- 11.6 vs. 107 +/- 12 mm Hg, p = 0.001), mean arterial (83.7 +/- 8.8 vs. 79.6 +/- 7.6 mm Hg, p = 0.002) and pulse (45.8 +/- 7.7 vs. 42.4 +/- 8.3 mm Hg, p = 0.001) pressure. On multivariable logistic regression analysis, only African American race (OR 3.1; 95% CI 1.13, 8.40; p = 0.028), and pulse pressure (OR 1.05; 95% CI 1.01, 1.1; P = 0.014) were independently associated with the development of preeclampsia.CONCLUSION: Primiparous women who later develop preeclampsia have an elevation in pulse, systolic and mean arterial pressure before 15 weeks.