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Delayed acute measles inclusion body encephalitis in a 9-year-old girl: ultrastructural, immunohistochemical, and in situ hybridization studies

Kim, T.M.; Brown, H.R.; Lee, S.H.; Powell, C.V.; Bethune, P.; Goller, N.L.; Tran, H.T.; Mackay, J.S.

Modern Pathology An Official Journal of the United States and Canadian Academy of Pathology Inc 5(3): 348-352

1992

ISSN/ISBN: 0893-3952
PMID: 1353879
Document Number: 397803
A 9-yr-old girl developed delayed acute measles inclusion body encephalitis, which was different from subacute sclerosing panencephalitis (SSPE) in clinical course. Measles virus was demonstrated by electron microscopy, immunohistochemistry, and in situ hybridization. Contrary to the most previous reports, matrix (M) protein was present in the brain, cerebrospinal fluid, and serum and was demonstrated by Western blot analysis and in situ hybridization. The hybridization was performed by a nonradioactive digoxigenin method.

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