Top Abstract Purchase Related
Home
>
Node
>
Subnode

Histological changes in the retinal pigment epithelium and Bruch's membrane in senescence accelerated mouse

Ogata, N.; Ohkuma, H.; Kanai, K.; Nango, K.; Takada, Y.; Uyama, M.

Nippon Ganka Gakkai Zasshi 96(2): 180-189

1992

ISSN/ISBN: 0029-0203
PMID: 1558013
Document Number: 396707
Senescence associated changes of the retinal pigmented epithelium (RPE) and Bruch's membrane were investigated in senescence accelerated mouse (SAM), which is an aging model mouse, by light and electron microscopy. The most characteristic changes in RPE were swelling of basal infoldings, extension of intercellular space and accumulation of lipofuscin granules. In Bruch's membrane, discontinuation of elastic layer and abnormal increase of fine fibrils in the outer collagenous layer were observed. The aging changes in SAM were severer in the posterior retina than in the peripheral one. Moreover, these changes were seen younger age than in those of the normal BALB/c mouse.

Document emailed within 1 workday
Secure & encrypted payments

Asahara, N. 1978: Ultrastructural observations of the choroid-Bruch's membrane-pigment epithelium on an extensive retinochoroidal detachment associated with nanophthalmos Nippon Ganka Gakkai Zasshi 82(3): 181-190
Kondo, K. 1979: Ultrastructural observations of age changes in the mouse retinal pigment epithelium. I. Quantitative analysis Nippon Ganka Gakkai Zasshi 83(7): 707-720
Li, W.W.; Yew, D.T. 1988: Responses of the retinal pigment epithelium of the mouse after acute loss of blood Acta Anatomica 133(4): 337-340
Strubbe, M.; De Laey, J.J. 1992: Retinal periphlebitis and retinal pigment epithelium changes associated with multiple sclerosis: a report of two cases Bulletin de la Societe Belge d'Ophtalmologie 245: 65-68
Men, G.; Peyman, G.A.; Kuo, P-Cheng.; Ghahramani, F.; Canakis, C.; Ratnakaram, R.; Bezerra, Y. 2003: The effect of intraoperative retinal manipulation on the underlying retinal pigment epithelium: an experimental study Retina 23(4): 475-480
Verma, L.; Venkatesh, P.; Lakshmaiah, C.N.; Tewari, H.K. 2000: Combined hamartoma of the retina and retinal pigment epithelium with full thickness retinal hole and without retinoschisis Ophthalmic Surgery and Lasers 31(5): 423-426
Kwok, A.K.H.; Lam, S.W.; Lai, T.Y.Y.; Lam, D.S.C. 2002: Endophotocoagulation to retinal pigment epithelium as an adjuvant therapy in the management of retinal detachment caused by a highly myopic macular hole Ophthalmic Surgery and Lasers 33(2): 155-157
Lv, L.; Zhong, Z.; Wu, D.; Chai, L.; Zhang, W. 2009: Effect of Panax notoginseng saponins on syp and tau gene expression in brain of senescence accelerated mouse Zhongguo Zhong Yao Za Zhi 34(10): 1261-1263
Hogan, M.J. 1972: Role of the retinal pigment epithelium in macular disease Transactions - American Academy of Ophthalmology and Otolaryngology. American Academy of Ophthalmology and Otolaryngology 76(1): 64-80
Asayama, K. 1979: Study on the function of microvilli in the rat retinal pigment epithelium Nippon Ganka Gakkai Zasshi 83(7): 721-732
Vandeveer, M. 1986: Combined hamartoma of the retinal pigment epithelium and sensory retina Journal of the American Optometric Association 57(11): 836-838
Fernández, P.; Teutsch, P.; Maldonado, M.J.; Moreno-Montañés, J.; Rodríguez, J.A.; García-Layana, A. 2001: Ultrastructural changes of the retinal pigment epithelium in pigs fed with a fat rich diet Archivos de la Sociedad Espanola de Oftalmologia 76(2): 125-132
Anh, J.N. 1972: Myeloid bodies of the retinal pigment epithelium. II. Origin and ultracytochemistry Zeitschrift für Zellforschung und mikroskopische Anatomie 131(2): 187-198
Del Monte, M.A.; Maumenee, I.H. 1980: New technique for in vitro culture of human retinal pigment epithelium Birth Defects Original Article Series 16(2): 327-338
Nomura, Y. 1994: Experimental techniques for developing new drugs acting on dementia (1)--Senescence-accelerated mouse: neurochemical approaches and the findings Nihon Shinkei Seishin Yakurigaku Zasshi 14(3): 139-146
Hasebe, H. 1979: Histogenesis of the chick embryo retinal pigment epithelium. 1. the early ontogenesis Nippon Ganka Gakkai Zasshi 83(4): 344-360
Potter, J.W.; Thallemer, J.M. 1981: Geographic atrophy of the retinal pigment epithelium: diagnosis and vision rehabilitation Journal of the American Optometric Association 52(6): 503-508
Flood, M.T.; Gouras, P.; Haley, J.E.; Blaner, W.S. 1982: Human retinal pigment epithelium in vitro: organization, ultrastructure, and biochemistry Birth Defects Original Article Series 18(6): 53-66
Braekevelt, C.R. 1990: Circadian changes in the retinal pigment epithelium of the butterfly fish (Pantodon buchholzi) Anatomischer Anzeiger 171(4): 284-292
Hewitt, A.T.; Newsome, D.A. 1987: Altered glycoconjugates in cultures of retinitis pigmentosa retinal pigment epithelium Progress in Clinical and Biological Research 247: 79-92