Liver and brain DNA contents in acute soman intoxication
Skopec, F.; Bajgar, J.
Sbornik Vedeckych Praci Lekarske Fakulty Karlovy University V Hradci Kralove 35(3): 253-262
1992
ISSN/ISBN: 0049-5514 PMID: 1488604 Document Number: 396269
Contents of DNA in the liver and brain parts (cerebellum, pons, hemispheres) of the rat following acute intoxication with soman (i. m., 32 micrograms/kg) were studied. Statistically significant increase of DNA concentrations in the liver and decrease in the hemispheres 1 and 3 hours after the intoxication was demonstrated; in other brain parts studied, no changes were detected. The blood acetylcholinesterase activity was diminished 1 hour after the injection of soman and it was statistically significant 3 days following poisoning. In rats pretreated with atropinee (i. m., 200 mg/kg) and intoxicated with higher dose of soman (i. m., 50 micrograms/kg), specific activity of incorporation of radiolabelled thymidine into DNA was significantly decreased in the liver only. The results suggested that soman except cholinergic effects also influenced metabolism of nucleic acids.