Utilization of a multiparametric technique for analysis of specificity of different inhibitors of various forms of cyclic nucleotide phosphodiesterases
Lugnier, C.; Doré, J.C.; Stoclet, J.C.; Viel, C.
Die Pharmazie 47(1): 46-49
1992
ISSN/ISBN: 0031-7144 PMID: 1319070 Document Number: 396074
Multiple enzymes and compounds were used to study relationship between chemical structure and enzymatic affinity. Reduction of multidimensional data, by mathematical methods, as factorial correspondence analysis (FCA), with simple graphical representation allows to define the relative specificity of various molecules for different enzymatic targets. Using a significative sample of molecule tests and their biological responses it would be possible for each new compound to determine its typology inside its molecular family and to give insight for pharmacological modulation. Papaverine analogues reference drugs and three isolated cyclic nucleotide phosphodiesterase forms were used as experimental model in this analysis.