The influence of oligodeoxyribonucleotide phosphorothioate pyrimidine strands on triplex stability
Tsukahara, S.; Kim, S.G.; Takaku, H.
Nucleic Acids Symposium Series 27: 121-122
1992
ISSN/ISBN: 0261-3166 PMID: 1289787 Document Number: 396020
The analogues of the homopyrimidine oligonucleotide dT15 has been synthesized. The analogues, contains phosphorothioate bonds of a mixture of diastereoisomers or one of the two stereoisomer (either Rp or Sp). The analogues were mixed under conditions conductive to the formation of triple stranded assemblies. The mixtures were characterized by their thermal stabilities (Tm values) and CD spectra.
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