Top Abstract Purchase Related
Home
>
Node
>
Subnode

Circadian variations of phenacetin metabolism in rats in vivo and in vitro

Starek, A.

Polish Journal of Pharmacology and Pharmacy 44(6): 663-670

1992

ISSN/ISBN: 0301-0244
PMID: 1305962
Document Number: 395797
The metabolism of phenacetin in vivo and in vitro at different periods of day was investigated in rats. In rats maintained on standard LD conditions the disappearance rate of phenacetin from blood and activity of phenacetin O-deethylase in liver were the highest in the morning and the lowest in the evening. Continuous illumination, adrenalectomy, phenobarbital or proadifen abolished this difference. It is postulated that these circadian changes of microsomal metabolism of phenacetin in rats liver are not fully responsible for the rhythmical changes in the antipyretic action of this drug that was observed previously. The mechanisms of this phenomenon are discussed.

Document emailed within 1 workday
Secure & encrypted payments

Kuperman, A.V.; Kalgutkar, A.S.; Marfat, A.; Chambers, R.J.; Liston, T.E. 2001: Pharmacokinetics and metabolism of a cysteinyl leukotriene-1 receptor antagonist from the heterocyclic chromanol series in rats: in vitro-in vivo correlation, gender-related differences, isoform identification, and comparison with metabolism in human hepatic tissue Drug Metabolism and Disposition: the Biological Fate of Chemicals 29(11): 1403-1409
Gallenkamp, H.; Wilhelm, T.; Zilly, W.; Richter, E. 1976: Metabolism in vitro and metabolic clearance in vivo of tolbutamide in rats with experimental cholestasis Verhandlungen der Deutschen Gesellschaft für Innere Medizin 82 Pt 1: 297-300
Müller, O. 1972: Circadian variations in barbiturate response in rats Verhandlungen der Deutschen Gesellschaft für Pathologie 56: 498-502
Dorian, C.; Cambar, J. 1986: Circadian variations of amikacin nephrotoxicity in rats Pathologie-Biologie 34(5 Part 2): 587-590
Lan, S.J.; Chando, T.J.; Cohen, A.I.; Weliky, I.; Schreiber, E.C. 1973: Metabolism of 4-(3-(dimethylamino)propyl)-3,4-dihydro-2-(1-hydroxyethyl)-3-phenyl-2H-1,4-benzothiazine (SQ 11,579) under in vitro and in vivo conditions by rats, dogs, and monkey Drug Metabolism and Disposition: the Biological Fate of Chemicals 1(4): 619-627
Shurlygina, A.V.; Trufakin, V.A.; Gushchin, G.V.; Korneva, E.A. 1999: Circadian variations of adrenaline, noradrenaline, and beta-adrenoreceptor levels in blood and lymphatic organs of healthy rats Biulleten' Eksperimental'noi Biologii i Meditsiny 128(9): 344-346
Sinzinger, H.; Rogatti, W. 1994: Prostaglandins and arterial wall lipid metabolism--in vitro, ex-vivo and in-vivo radioisotopic studies Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society 45(1): 27-40
Obled, C.; Arnal, M.; Fauconneau, G. 1972: Circadian rhythm of in-vivo protein synthesis in various tissues of growing rats: effect of the alimentary behavior Comptes Rendus des Seances de la Societe de Biologie et de ses Filiales 166(6): 885-891
Ge, Z.H.; Li, H.; Liu, C.G.; Ruan, J.X. 1997: In vivo and in vitro metabolism of tricyclopinate hydrochloride in the rat Yao Xue Xue Bao 32(9): 652-657
Glogner, P.; Ermert, A. 1970: Study of phenacetin metabolism Arzneimittel-Forschung 20(5): 636-637
Hanlon, M.H.; Ferone, R.; Mullin, R.J.; Keith, B.R. 1990: In vivo and in vitro metabolism of 5-deazaacyclotetrahydrofolate, an acyclic tetrahydrofolate analogue Cancer Research 50(11): 3207-3211
Roberts, A.B.; Frolik, C.A. 1979: Recent advances in the in vivo and in vitro metabolism of retinoic acid Federation Proceedings 38(11): 2524-2527
Seibert, G.; Maidhof, A.; Zahn, R.K.; Müller, W.E. 1978: Tubercidin metabolism in mouse L5178y cells in vivo and in vitro Gan 69(6): 739-747
Olson, M.J.; Johnson, J.T.; O'Gara, J.F.; Surbrook, S.E. 1991: Metabolism in vivo and in vitro of the refrigerant substitute 1,1,1,2-tetrafluoro-2-chloroethane Drug Metabolism and Disposition: the Biological Fate of Chemicals 19(5): 1004-1011
Dann, R.E.; Mitscher, L.A.; Couri, D. 1972: The in vivo metabolism of 14 C-labeled aflatoxins B 1 , B 2 , G 1 in rats Research Communications in Chemical Pathology and Pharmacology 3(3): 667-675
Nicol, M.; Savouré, N.; Leray, G. 1972: Experimental metabolism of dehydroepiandrosterone in rats, in vivo Comptes Rendus des Seances de la Societe de Biologie et de ses Filiales 166(10): 1356-1360
Gallenkamp, H.; Sundermann, D.; Brachtel, D.; Grün, M.; Rasenack, U.; Rietbrock, I.; Liehr, H.; Richter, E. 1974: Effect of a choline-deficient diet on drug metabolism in the rat in vivo and in vitro Verhandlungen der Deutschen Gesellschaft für Innere Medizin 80: 1558-1561
Fishman, R.A.; Chan, P.H. 1976: Changes in ammonia and amino acid metabolism induced by hyperosmolality in vivo and in vitro Transactions of the American Neurological Association 101: 34-39
Remmer, H. 1976: Drug metabolism in the human liver measured with in vitro and in vivo methods Arzneimittel-Forschung 26(6): 1262-1263
Donenko, F.V.; Chikvashvili, B.S.; Borovkova, N.B.; Devichenskiĭ, V.M.; Kabieva, A.O.; Korneva, E.N.; Telegin, L.I.; Shcherbakov, V.M.; Letiagin, V.P.; Moroz, L.V. 1991: The effect of finoptin on the metabolism and pharmacological action of cyclophosphane in vivo and in vitro Biulleten' Eksperimental'noi Biologii i Meditsiny 111(3): 300-302