Study of selegiline and related compounds with x-ray diffraction
Simon, K.; Böcskei, Z.; Török, Z.
Acta Pharmaceutica Hungarica 62(5): 225-230
1992
ISSN/ISBN: 0001-6659 PMID: 1488906 Document Number: 395464
Selegiline and its parent compounds were studied by X-ray diffraction. It was established that the racemates of primary and secondary amines (p-fluoro-amphetamine, methamphetamine, p-fluoro-methamphetamine) hydrochloride do not form racemic compounds but crystalline as conglomerates, at the same time tertiary amines like selegiline and p-fluoro-selegiline hydrochlorides do. The crystalline structure of five enantiomeric hydrochlorides were determined, the CPhe-C-C-N torsion angle is anti-periplanar in all cases but in p-fluoro-amphetamine where it is gauche.